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[氙气与其他麻醉剂麻醉期间“脑氧饱和度测定”的比较评估]

[A comparative evaluation of "cerebral oximetry" during anesthesia with xenon and other anesthetics].

作者信息

Sal'nikov P S, Burov N E

出版信息

Anesteziol Reanimatol. 2003 May-Jun(3):35-7.

PMID:12918199
Abstract

The oxygen status dynamics during the general anesthesia is one of the most important issues of anesthetic monitoring. The set target was to study the cerebral oximetry (rSO2) in anesthesia with xenon as compared with other anesthetics. A total of 80 patients (class ASA I-II) were examined in the venectomy surgery. According to an anaesthetic used in induction and anesthesia management, the patients were divided into 3 groups. Group 1--40 patients with xenon mono-anesthesia; group 2--20 patients with propofol + N2O + neurolpangesia; and group 3--20 patients with N2O + ftorotan. At xenon induction, rSO2 went up by 6.4%. At propofol induction, there were no changes in rSO2. A biggest increase in the cerebral blood circulation was noted, at the anesthesia management stage, in the patients' group, who received ftorotan; a lesser increase was registered in xenon anesthesia. An increased rSO2 level was higher, during the wakening stage, in case of ftorotan administration than in the group, which received xenon; the process of recovering the initial parameters was slower in the former group. Xenon and ftorotan were shown to contribute to a higher oxygen status and an increased volume of the cerebral blood circulation. In case of xenon mono-anesthesia, there was a smaller increase in the cerebral blood circulation as compared to N2O + ftoratan anesthesia. Further special investigations are needed to give a final answer to the question on whether it is possible to use xenon in neuroanesthesiology and in intensive care of patients with a neuroresuscitation-type pathology of the brain.

摘要

全身麻醉期间的氧状态动态是麻醉监测最重要的问题之一。设定的目标是研究氙气麻醉与其他麻醉剂相比时的脑氧饱和度(rSO2)。共有80例(ASA I-II级)患者接受了静脉切除术。根据诱导和麻醉管理中使用的麻醉剂,将患者分为3组。第1组——40例接受氙气单一麻醉的患者;第2组——20例接受丙泊酚+氧化亚氮+神经安定镇痛的患者;第3组——20例接受氧化亚氮+氟烷的患者。在氙气诱导时,rSO2上升了6.4%。在丙泊酚诱导时,rSO2没有变化。在麻醉管理阶段,接受氟烷的患者组脑血流量增加最大;氙气麻醉时增加较小。在苏醒阶段,给予氟烷时rSO2升高水平高于接受氙气的组;前一组恢复初始参数的过程较慢。结果显示,氙气和氟烷有助于提高氧状态和增加脑血流量。与氧化亚氮+氟烷麻醉相比,氙气单一麻醉时脑血流量增加较小。关于氙气是否可用于神经麻醉学以及脑复苏型脑部病理患者的重症监护,还需要进一步的专门研究才能给出最终答案。

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