Behavioral and endocrine effects of endotoxin in wild-type mice and mice deficient in interleukin 1: sickness behavior or adaptive response?

作者信息

Moshkin M P, Tamagawa A, Kolosova I E, Gerlinskaya L A, Iwakura Y, Endo Y

机构信息

Institute of Systematics and Ecology of Animals, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630091 Russia.

出版信息

Dokl Biol Sci. 2001 Jul-Aug;379:322-4. doi: 10.1023/a:1011687810496.

DOI:10.1023/a:1011687810496

PMID:12918364

Abstract

摘要

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Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.对白介素（IL）-1α、IL-1β、IL-1α/β以及白介素-1受体拮抗剂基因缺失小鼠的研究表明，IL-1β在松节油诱导的发热及糖皮质激素分泌过程中起关键作用。

J Exp Med. 1998 May 4;187(9):1463-75. doi: 10.1084/jem.187.9.1463.

Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs.内毒素诱导小鼠社会探究行为减少：与苯丙胺和抗炎药物的相互作用。

Psychopharmacology (Berl). 1997 Aug;132(4):335-41. doi: 10.1007/s002130050353.

Role of corticosterone in the behavioral effects of central interleukin-1 beta.

Physiol Behav. 1997 Jan;61(1):7-13. doi: 10.1016/s0031-9384(96)00350-2.

Meal patterns in response to the intracerebroventricular administration of interleukin-1 beta in rats.大鼠脑室内注射白细胞介素-1β后的进食模式。

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Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice.

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Neurosci Biobehav Rev. 1988 Summer;12(2):123-37. doi: 10.1016/s0149-7634(88)80004-6.

Sickness behavior as a new target for drug development.疾病行为作为药物研发的新靶点。

Trends Pharmacol Sci. 1992 Jan;13(1):24-8. doi: 10.1016/0165-6147(92)90012-u.

Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration.

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