Bradley Elizabeth A, Hodge David O, Bartley George B
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Ophthalmic Plast Reconstr Surg. 2003 May;19(3):177-81. doi: 10.1097/01.iop.0000065203.88182.cf.
To describe the incidence, patient demographics, and response to treatment of benign essential blepharospasm (BEB) in a population-based cohort.
In this epidemiologic study, we searched the Rochester Epidemiology Project database for patients diagnosed with blepharospasm or related disorders between 1976 and 1995. The incident rate denominator was based on a linear interpolation of decennial census data from Olmsted County. The 95% confidence interval for the incidence rate was based on the Poisson distribution.
Olmsted County residents (n = 295) were diagnosed with blepharospasm or related disorders between 1976 and 1995. Of these, 8 patients met the criteria for BEB. The calculated incidence rate of BEB is 1.2 persons per 100,000 population per year (95% CI, 0.37 to 2.02). At the time of BEB diagnosis, the median patient age was 61.5 years, and symptoms had been present for a median of 24 months. Four patients were men and 4 were women. Four of the 8 patients had Meige syndrome. Three of 4 patients treated with oral medications reported symptomatic improvement. Botulinum toxin injection was offered to all patients, but only 4 elected treatment. All who were treated with botulinum toxin had temporary symptomatic improvement. No patient underwent surgical treatment for BEB. Two patients had resolution of symptoms within the follow-up period.
BEB is a rare disorder. In this small, population-based sample, women and men were affected with equal frequency, and half of patients had lower facial dystonia (Meige syndrome). Only half of patients with BEB elected botulinum toxin injections, and none required surgery. Disease remission occurred in 2 of 8 patients.
描述基于人群队列中良性原发性眼睑痉挛（BEB）的发病率、患者人口统计学特征及治疗反应。
在这项流行病学研究中，我们在罗切斯特流行病学项目数据库中搜索了1976年至1995年间被诊断为眼睑痉挛或相关疾病的患者。发病率分母基于奥尔姆斯特德县十年一次人口普查数据的线性插值。发病率的95%置信区间基于泊松分布。
1976年至1995年间，奥尔姆斯特德县居民（n = 295）被诊断为眼睑痉挛或相关疾病。其中，8例患者符合BEB标准。计算得出的BEB发病率为每年每100,000人口中有1.2人（95% CI，0.37至2.02）。在BEB诊断时，患者的中位年龄为61.5岁，症状出现的中位时间为24个月。4例为男性，4例为女性。8例患者中有4例患有Meige综合征。4例接受口服药物治疗的患者中有3例报告症状改善。所有患者均接受了肉毒杆菌毒素注射，但只有4例选择治疗。所有接受肉毒杆菌毒素治疗的患者症状均有暂时改善。没有患者因BEB接受手术治疗。2例患者在随访期内症状缓解。
BEB是一种罕见疾病。在这个基于人群的小样本中，男性和女性受影响的频率相同，且一半的患者患有面下部肌张力障碍（Meige综合征）。只有一半的BEB患者选择肉毒杆菌毒素注射，且无人需要手术。8例患者中有2例疾病缓解。
