Mann K J, Dousa D M, Kerrigan R J, Berndt T J, Knox F G
Department of Physiology, Mayo Clinic, Rochester, Minn 55905.
Miner Electrolyte Metab. 1992;18(6):354-8.
Acute renal denervation (DNX) has been reported to increase urinary phosphate (Pi) excretion in rats with intact parathyroid glands and also in rats which were thyroparathyroidectomized (TPTX). The present study was performed to determine the effects of acute renal denervation on the tubular transport of Pi in rats in the absence of parathyroid hormone (PTH) and in rats with constant PTH levels. In TPTX rats, the reabsorbed Pi normalized for the glomerular filtration rate (Reab Pi/GFR) was 2.38 +/- 0.16 mumol/ml in the DNX kidney compared to 2.56 +/- 0.16 mumol/ml (p < 0.05) in the contralateral innervated (INN) kidney at endogenous plasma phosphate levels (n = 6). The lower values for the Reab Pi/GFR in the DNX kidney persisted at elevated plasma phosphate concentrations during phosphate infusions. Infusion of PTH resulted in markedly lower Reab Pi/GFR values in the innervated kidney (1.47 +/- 0.21 mumol/ml) at endogenous plasma phosphate levels than in the vehicle-infused group. Furthermore, the Reab Pi/GFR in the DNX kidney was decreased (1.21 +/- 0.14 mumol/ml, n = 6) compared to the contralateral INN kidney. These studies demonstrate that acute renal DNX decreases the tubular transport of Pi both in the absence and in the presence of constant PTH levels.
据报道，急性肾去神经支配（DNX）可增加甲状旁腺完整大鼠以及甲状腺甲状旁腺切除（TPTX）大鼠的尿磷（Pi）排泄。本研究旨在确定急性肾去神经支配对无甲状旁腺激素（PTH）大鼠和PTH水平恒定大鼠肾小管Pi转运的影响。在内源性血浆磷酸盐水平下，TPTX大鼠中，去神经支配肾脏中经肾小球滤过率校正的重吸收Pi（Reab Pi/GFR）为2.38±0.16μmol/ml，而对侧有神经支配（INN）的肾脏中为2.56±0.16μmol/ml（p<0.05）（n=6）。在输注磷酸盐期间血浆磷酸盐浓度升高时，去神经支配肾脏中Reab Pi/GFR的较低值持续存在。在内源性血浆磷酸盐水平下，输注PTH导致有神经支配肾脏中的Reab Pi/GFR值（1.47±0.21μmol/ml）明显低于输注赋形剂组。此外，与对侧有神经支配的肾脏相比，去神经支配肾脏中的Reab Pi/GFR降低（1.21±0.14μmol/ml，n=6）。这些研究表明，急性肾去神经支配在无PTH和PTH水平恒定的情况下均会降低肾小管对Pi的转运。
