Gabryelski Wojciech, Wu Fengwu, Froese Kenneth L
Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Anal Chem. 2003 May 15;75(10):2478-86. doi: 10.1021/ac026466c.
Haloacetic acids (HAAs) are major byproducts of chlorination of drinking water. Electrospray ionization high-field asymmetric waveform ion mobility spectrometry mass spectrometry (ESI-FAIMS-MS) provides a tool for direct monitoring of these compounds. However, treated drinking water samples can be challenging to analyze due to the large number of chemicals present and due to matrix effects that can hinder quantitation of analytes. We developed a standard addition ESI-FAIMS-MS method that permits submicrogram per liter detection of haloacetic acids and overcomes matrix effects. An advantage of FAIMS is increased selectivity through a significant reduction in the chemical background from ESI. Moreover, detection limits with this method are much lower than with previously existing GC and GC/MS methods, and quantitation results compare favorably with other existing methods. This new method does not require sample preparation or chromatographic separation and provides a fast, simple, sensitive, and selective method for monitoring HAAs.
卤乙酸（HAAs）是饮用水氯化消毒的主要副产物。电喷雾电离高场不对称波形离子迁移谱质谱联用仪（ESI-FAIMS-MS）为直接监测这些化合物提供了一种工具。然而，由于处理后的饮用水样品中存在大量化学物质，且存在可能阻碍分析物定量的基质效应，因此对其进行分析具有挑战性。我们开发了一种标准加入ESI-FAIMS-MS方法，该方法能够实现每升亚微克级的卤乙酸检测，并克服基质效应。FAIMS的一个优点是通过显著降低ESI产生的化学背景来提高选择性。此外，该方法的检测限远低于现有气相色谱（GC）和气相色谱/质谱联用（GC/MS）方法，定量结果与其他现有方法相比具有优势。这种新方法无需样品制备或色谱分离，为监测卤乙酸提供了一种快速、简单、灵敏且具有选择性的方法。
