Mańko-Juraszek R, Kasperek S
Oddziału Neurologicznego Wojewódzkiego Szpitala Zespolonego, Bielsku-Białej.
Neurol Neurochir Pol. 1992 Sep-Oct;26(5):711-5.
In a patient aged 16 behaviour at changes, followed by visual agnosia, aphasia, paraparesis and involuntary movements developed about the 24th week of pregnancy. The presence of measles virus antibodies in the cerebrospinal fluid and progressing course of the disease with fever suggested SSPE. Pregnancy was terminated by caesarean section in the 30th week of pregnancy, the male premature baby died after 4 days, his brain was not examined under microscope. The mother died 2 weeks after labour in decerebrate rigidity. In the brain numerous profuse infiltrations composed of lymphocytes and plasma cells were found around blood vessels, the glia was proliferated and hypertrophied, eosinophilic inclusions were demonstrated in the nucleic of cortical neurons. The authors review the very few case, reported as yet, of SSPE in pregnant women. During pregnancy natural immunosuppression occurs, which may lead to activation of dormant infection with measles virus mutant. However, the history of one of the published cases suggests the possibility of other pathogenetic factors active in such cases.
一名16岁患者在孕期约第24周时出现行为改变，随后发展为视觉失认、失语、双侧轻瘫及不自主运动。脑脊液中存在麻疹病毒抗体且疾病伴有发热不断进展提示为亚急性硬化性全脑炎（SSPE）。妊娠在孕30周时通过剖宫产终止，男早产婴4天后死亡，未对其大脑进行显微镜检查。母亲在分娩后2周死于去大脑强直。在大脑中，血管周围发现大量由淋巴细胞和浆细胞组成的丰富浸润，神经胶质细胞增生肥大，在皮质神经元细胞核中可见嗜酸性包涵体。作者回顾了迄今为止报道的孕妇患SSPE的极少数病例。孕期会发生自然免疫抑制，这可能导致麻疹病毒突变体的潜伏感染激活。然而，已发表病例之一的病史提示在这类病例中可能存在其他致病因素。
