尼古丁作为常染色体显性遗传夜间额叶癫痫（ADNFLE）的抗癫痫药物：一项单病例研究
Nicotine as an antiepileptic agent in ADNFLE: an N-of-one study.
作者信息
Willoughby John O, Pope Kenneth J, Eaton Vaughn
机构信息
Centre for Neuroscience and Department of Medicine (Neurology) School of Informatics and Engineering Division of Pharmacy, Flinders University and Medical Centre, Adelaide, South Australia, Australia. John.@
出版信息
Epilepsia. 2003 Sep;44(9):1238-40. doi: 10.1046/j.1528-1157.2003.58102.x-i1.
PURPOSE
To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy.
METHODS
Open and double-blind trials of nicotine patches in an "n-of-one" study. The double-blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double-blind manner.
RESULTS
In an open study, nicotine patches reduced seizures from 1.65 +/- 2.36 to 0.01 +/- 0.0 seizures per day (p < 0.0001). In a double-blinded placebo-controlled phase, the average frequency of seizures on nicotine versus placebo was 0 +/- 0 versus 0.56 +/- 1.14 seizures per day (p < 0.0001).
CONCLUSIONS
Nicotine patches may be of benefit to some individuals with ADNFLE.
目的
对一名患有常染色体显性遗传性夜间额叶癫痫（ADNFLE）特定突变且癫痫发作对标准抗癫痫治疗无效的患者进行尼古丁贴片治疗测试。
方法
在一项“单病例”研究中对尼古丁贴片进行开放试验和双盲试验。双盲试验包括分别使用安慰剂或尼古丁贴片各3个为期2周的阶段，采用双盲方式随机安排。
结果
在开放研究中，尼古丁贴片使癫痫发作次数从每天1.65±2.36次减少至0.01±0次（p<0.0001）。在双盲安慰剂对照阶段，使用尼古丁贴片与安慰剂时癫痫发作的平均频率分别为每天0±0次和0.56±1.14次（p<0.0001）。
结论
尼古丁贴片可能对部分ADNFLE患者有益。
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