[Detection of panel-reactive antibody before and after renal transplantation: analysis of 641 cases].

OBJECTIVE

To explore the significance of the panel-reactive antibody (PRA) detection in renal transplantation.

METHODS

Enzyme-linked immunosorbent assay (ELISA) was used to measure the PRA levels in 641 patients with renal transplantation, of whom 570 were examined preoperatively while 71 postoperatively.

RESULTS

Of the 570 cases examined preoperatively for PRA levels, 490 cases were negative of PRA in which acute rejection occurred in 35 cases (7.14%) after the transplantation, while in the 68 cases with slightly positive PRA as detected preoperatively, acute rejection occurred in 36 cases (52.9%). Among the 12 cases with positive PRA assay both before and after the operation, acute rejection took place in 10 cases (83.3%). As for the 71 patients receiving postoperative PRA detection, 59 were PRA-negative, among whom acute rejection occurred in only 3 cases (5.08%), while 7 (58.3%) out of the 12 PRA-positive experienced episodes of acute rejection.

CONCLUSION

PRA-positive recipients of the renal transplantation have higher risks of acute rejection of the graft, and PRA detection both before and after the operation may be of great importance.