Huang Yu-yu, Huang Ping, Lou Hui-ling
Department of Geriatrics, First People's Hospital of Guangzhou, Guangzhou 510055, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Aug;23(8):868-9.
To study the diagnostic values of detection of glutamic acid decarboxylase antibody (GAD-Ab) for latent autoimmune diabetes in adults (LADA).
The clinical characteristics, body mass index (BMI), serum C-peptide levels, and HbAIC were compared between the 12 type 2 diabetic patients positive and 86 negative for GAD-Ab.
The mean age, BMI, fasting and postprandial 2 h C-peptide levels in GAD-Ab-positive group were lower than those of GAD-Ab-negative group. The frequency of insulin use and prevalence of ketosis were higher in GAD-Ab-positive group than in GAD-Ab-negative group.
The diagnosis of LADA can be established according to GAD-Ab-positivity, clinical characteristics and islet function. Patients with LADA should receive insulin therapy as early as possible to protect the residue islet B cells, reduce the occurrence of ketosis, and prevent diabetic complications of the eye, kidney and nerves.
研究谷氨酸脱羧酶抗体（GAD - Ab）检测对成人隐匿性自身免疫性糖尿病（LADA）的诊断价值。
比较12例GAD - Ab阳性的2型糖尿病患者与86例GAD - Ab阴性的2型糖尿病患者的临床特征、体重指数（BMI）、血清C肽水平和糖化血红蛋白（HbA1c）。
GAD - Ab阳性组的平均年龄、BMI、空腹及餐后2小时C肽水平低于GAD - Ab阴性组。GAD - Ab阳性组胰岛素使用频率和酮症患病率高于GAD - Ab阴性组。
根据GAD - Ab阳性、临床特征及胰岛功能可确诊LADA。LADA患者应尽早接受胰岛素治疗，以保护残余胰岛B细胞，减少酮症发生，预防糖尿病眼、肾及神经并发症。
