局部散瞳剂和血管收缩剂对色素沉着兔前列腺素E2诱导的房水闪光升高的影响。
Effects of topical mydriatics and vasoconstrictors on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits.
作者信息
Hayasaka Yoriko, Hayasaka Seiji, Zhang Xue-Yun, Nagaki Yasunori
机构信息
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
出版信息
Ophthalmic Res. 2003 Sep-Oct;35(5):256-60. doi: 10.1159/000072146.
We evaluated the effects of topical instillation of mydriatics and vasoconstrictors on prostaglandin E2 (PGE2) induced aqueous flare elevation in pigmented rabbits. Transcorneal diffusion of PGE2 (25 microg/ml) by means of a glass cylinder produced aqueous flare elevation. Mydriatics (atropine sulfate, tropicamide, tropicamide plus phenylephrine hydrochloride, phenylephrine hydrochloride, and cyclopentolate hydrochloride) or vasoconstrictors (naphazoline nitrate and tramazoline hydrochloride) were topically administered before PGE2 application. Aqueous flare was measured with a laser flare-cell meter. One or two instillations of atropine sulfate 1.0%, tropicamide 0.4%, tropicamide 0.5% plus phenylephrine hydrochloride 0.5%, phenylephrine hydrochloride 5.0%, cyclopentrate hydrochloride 1.0%, and naphazoline nitrate 0.05% did not inhibit PGE2-induced aqueous flare elevation. Tramazoline hydrochloride 0.118% inhibited significantly (p < 0.05) PGE2-induced aqueous flare elevation. It is possible that vasoconstriction may be involved partly in inhibition of PGE2-induced aqueous flare elevation by some drugs in pigmented rabbits.
我们评估了在有色兔中，局部滴注散瞳药和血管收缩剂对前列腺素E2（PGE2）诱导的房水闪光升高的影响。通过玻璃圆柱体使PGE2（25微克/毫升）经角膜扩散，从而引起房水闪光升高。在应用PGE2之前，局部给予散瞳药（硫酸阿托品、托吡卡胺、托吡卡胺加盐酸去氧肾上腺素、盐酸去氧肾上腺素和盐酸环喷托酯）或血管收缩剂（硝酸萘甲唑啉和盐酸曲马唑啉）。用激光房水闪光细胞仪测量房水闪光。滴注1.0%的硫酸阿托品、0.4%的托吡卡胺、0.5%的托吡卡胺加0.5%的盐酸去氧肾上腺素、5.0%的盐酸去氧肾上腺素、1.0%的盐酸环喷托酯和0.05%的硝酸萘甲唑啉一次或两次，均未抑制PGE2诱导的房水闪光升高。0.118%的盐酸曲马唑啉能显著抑制（p<0.05）PGE2诱导的房水闪光升高。在有色兔中，血管收缩可能部分参与了某些药物对PGE2诱导的房水闪光升高的抑制作用。
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