NK/T细胞淋巴瘤的细胞学特征。
Cytologic features of NK/T-cell lymphoma.
作者信息
Chan Amy Bik-Wan, Chan Wing-Yee, Chow John Hei-Sing
机构信息
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, S.A.R., People's Republic of China.
出版信息
Acta Cytol. 2003 Jul-Aug;47(4):595-601. doi: 10.1159/000326574.
OBJECTIVE
To describe the diagnostic cytologic features of NK/T-cell lymphoma.
STUDY DESIGN
The cytologic features of 3 cases of natural killer cell (NK)/T-cell lymphoma were studied and correlated with histology. Immunohistochemistry for CD56, T-cell intracellular antigen (TIA-1) and EBV-encoded small nuclear RNAs (EBER) in situ hybridization was reviewed.
RESULTS
The lymphomas have mixed-sized cells with eccentric, round to ovoid nuclei; 1 or 2 prominent nucleoli; and abundant, clear to pale, eosinophilic cytoplasm. Mitotic figures, necrotic debris and tingible body macrophages are common accompaniments. In fluid, the lymphoma cells appear more shrunken. A clot section of 1 case was positive for CD56, TIA-1 and EBER.
CONCLUSION
Helpful cytologic features for the diagnosis of NK/T-cell lymphoma are described. Immunohistochemistry for CD56, TIA-1 and EBER in situ hybridization are very helpful adjuncts for the diagnosis.
目的
描述NK/T细胞淋巴瘤的诊断性细胞学特征。
研究设计
研究3例自然杀伤细胞（NK）/T细胞淋巴瘤的细胞学特征，并与组织学进行相关性分析。回顾性分析CD56、T细胞胞内抗原（TIA-1）免疫组化及EBV编码小核RNA（EBER）原位杂交结果。
结果
淋巴瘤细胞大小不一，核呈偏心圆形至卵圆形；有1或2个明显核仁；胞质丰富、清亮至淡嗜酸性。常见有丝分裂象、坏死碎片及吞噬含铁血黄素巨噬细胞。在体液中，淋巴瘤细胞显得更加皱缩。1例凝块切片CD56、TIA-1及EBER呈阳性。
结论
描述了有助于诊断NK/T细胞淋巴瘤的细胞学特征。CD56、TIA-1免疫组化及EBER原位杂交对诊断非常有帮助。
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