Martynov S A, Shvetsov M Iu, Kutyrina I M, Miroshnichenko N G, Kushnir V V, Petrov S V, Struchkova T Ia, Dzhanaliev B R, Varshavskiĭ V A, Proskurneva E P
Ter Arkh. 2003;75(6):41-6.
To examine blood flow in renal and intrarenal arteries and its changes in the acute pharmacological test with captopril in patients with chronic glomerulonephritis (CGN).
Renal circulation was studied in 50 patients with CGN using ultrasound dopplerography (USDG) of renal vessels on the unit GE Logiq 400 CL PRO Series. The velocity and indices of peripheral blood resistance in the major renal artery (RA) and in intrarenal arteries were estimated. In 26 patients the blood flow was studied again after intake of 50 mg captopril.
Poor renal blood flow was registered in cortical parenchyma in 36% CGN patients (with chronic renal failure in 75%). Multifactorial regression analysis has demonstrated that only blood creatinine was independently related with slowing down of the blood flow at the level of RA and intrarenal arteries. Morphological index of activity correlated with resistance indices while a high sclerosis index correlated with blood flow slowing. Older patients had higher resistance indices. Captopril significantly accelerated blood flow and insignificantly changed indices of peripheral resistance including those in CRF patients.
Poor blood flow in the cortical layer of renal parenchyma in CGN, according to USDG, occurs rather frequently and was associated with CRF and older age of the patients. Blocking of renin-angiotensin system at the level of angiotensin II formation improves renal blood flow in most of the patients.
研究慢性肾小球肾炎（CGN）患者在卡托普利急性药理试验中肾动脉和肾内动脉的血流情况及其变化。
使用GE Logiq 400 CL PRO系列设备上的肾血管超声多普勒成像（USDG）对50例CGN患者的肾循环进行研究。评估主要肾动脉（RA）和肾内动脉的外周血流阻力速度和指标。26例患者在服用50毫克卡托普利后再次研究血流情况。
36%的CGN患者（75%患有慢性肾衰竭）皮质实质肾血流不佳。多因素回归分析表明，只有血肌酐与RA和肾内动脉水平的血流减慢独立相关。活动形态学指标与阻力指标相关，而高硬化指数与血流减慢相关。老年患者的阻力指标更高。卡托普利显著加速了血流，对外周阻力指标（包括慢性肾衰竭患者的指标）的改变不显著。
根据USDG，CGN患者肾实质皮质层血流不佳相当常见，且与慢性肾衰竭和患者年龄较大有关。在血管紧张素II形成水平阻断肾素-血管紧张素系统可改善大多数患者的肾血流。
