Ren Xiao-long, Zhu Ren-zhi, Wang Li-jing, Zhang Ming-li, Li Dong-hai, Deng Xiao-qun
Department of Ultrasonography, Lanzhou First People Hospital, Lanzhou 730050, China.
Zhonghua Zhong Liu Za Zhi. 2003 Jul;25(4):368-71.
To investigate the relation of heparanase gene and angiogenesis with the progress of gastric carcinoma (GC).
Expression of heparanase mRNA in 52 GC tissue was detected by in situ hybridization assay. Microvessel density (MVD) was examined by immunohistochemical method. MVD and heparanase mRNA expression were analysed with their relation to histological grade, invasion depth,lymph node metastasis and organ metastasis.
MVD was 73.2 +/- 22.8 in 25 (48.1%) tissue with positive heparanase mRNA. It was 44.8 +/- 11.9 in 27 (51.9%) tissues with negative heparanase mRNA, between which the difference was significant (P < 0.001). MVD and heparanase mRNA expression were related with lymph node metastasis and depth of serosal invasion in GC (P < 0.005).
Heparanase, being related to angiogenesis in gastric cancer, promotes growth, invasion and metastasis. Heparanase mRNA expression is an important predictor of the biological behavior of human gastric carcinoma.
探讨乙酰肝素酶基因及血管生成与胃癌进展的关系。
采用原位杂交法检测52例胃癌组织中乙酰肝素酶mRNA的表达。用免疫组织化学方法检测微血管密度（MVD）。分析MVD及乙酰肝素酶mRNA表达与组织学分级、浸润深度、淋巴结转移及脏器转移的关系。
25例（48.1%）乙酰肝素酶mRNA阳性组织的MVD为73.2±22.8。27例（51.9%）乙酰肝素酶mRNA阴性组织的MVD为44.8±11.9，两者差异有统计学意义（P<0.001）。MVD及乙酰肝素酶mRNA表达与胃癌的淋巴结转移及浆膜浸润深度有关（P<0.005）。
乙酰肝素酶与胃癌血管生成有关，促进肿瘤生长、浸润及转移。乙酰肝素酶mRNA表达是预测人胃癌生物学行为的重要指标。
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