脂质乳剂在全合一溶液中混合后的过氧化潜力。

Peroxidation potential of lipid emulsions after compounding in all-in-one solutions.

作者信息

Pironi Loris, Guidetti Mariacristina, Zolezzi Carola, Fasano Maria Cinzia, Paganelli Federica, Merli Cecilia, Bersani Germana, Pizzoferrato Arturo, Miglioli Mario

机构信息

Departement of Internal Medicine and Gastroenterology, Bologna, Italy.

出版信息

Nutrition. 2003 Sep;19(9):784-8. doi: 10.1016/s0899-9007(03)00099-6.

DOI:10.1016/s0899-9007(03)00099-6

PMID:12921890

Abstract

OBJECTIVES

We investigated the peroxidation potential of fat emulsions in all-in-one solutions (AIOs).

METHODS

Three 20% emulsions were compared: soybean oil (SO; 60% polyunsaturated fatty acids [PUFAs], alpha-tocopherol:PUFAs = 0.44), soybean plus medium-chain triacylglycerol (SO-MCT; 31% PUFAs, alpha-tocopherol:PUFAs = 0.35), and olive oil (OO; 21% PUFAs, alpha-tocopherol:PUFAs = 1.42). For each emulsion, six AIO solutions were prepared by adding 250 mL of emulsion to a lipid-free solution. Lipid peroxide (LPX) and malondialdehyde (MDA) concentrations were evaluated in fat emulsions, lipid-free solutions, and AIOs immediately (T0) and 24 h (T24) after lipid addition. Statistical analysis was done with analysis of variance.

RESULTS

Fat emulsion LPX in SO-MCT was lower than that in SO (P = 0.015) and OO (P = 0.024); LPX in SO was greater than that in OO (P = 0.013); MDA in SO was greater than that in SO-MCT (P = 0.001) and OO (P = 0.013); and MDA in SO-MCT was greater than that in OO (P = 0.001). In comparison with MDA at AIO-T0, MDA at AIO-T24 increased in SO (P = 0.005) and SO-MCT (P < 0.001) and decreased in OO (P = 0.003); at AIO-T24, LPX was greater in SO, but not significantly.

CONCLUSIONS

In AIO bags, LPX occurred within 24 h after the addition of the lipid emulsion and seemed to be directly related to the PUFA content and inversely related to the alpha-tocopherol:PUFA ratio of the emulsion.

摘要

目的

我们研究了全合一溶液（AIOs）中脂肪乳剂的过氧化潜力。

方法

比较了三种20%的乳剂：大豆油（SO；60%多不饱和脂肪酸[PUFAs]，α-生育酚：PUFAs = 0.44）、大豆油加中链甘油三酯（SO-MCT；31% PUFAs，α-生育酚：PUFAs = 0.35）和橄榄油（OO；21% PUFAs，α-生育酚：PUFAs = 1.42）。对于每种乳剂，通过向无脂溶液中加入250 mL乳剂制备六种AIO溶液。在加入脂质后立即（T0）和24小时（T24）测定脂肪乳剂、无脂溶液和AIOs中的脂质过氧化物（LPX）和丙二醛（MDA）浓度。采用方差分析进行统计分析。

结果

SO-MCT中的脂肪乳剂LPX低于SO（P = 0.015）和OO（P = 0.024）；SO中的LPX高于OO（P = 0.013）；SO中的MDA高于SO-MCT（P = 0.001）和OO（P = 0.013）；SO-MCT中的MDA高于OO（P = 0.001）。与AIO-T0时的MDA相比，AIO-T24时SO（P = 0.005）和SO-MCT（P < 0.001）中的MDA增加，OO中的MDA降低（P = 0.003）；在AIO-T24时，SO中的LPX更高，但无显著差异。