Mavragani C P, Moutsopoulos H M
Department of Pathophysiology, School of Medicine, National University of Athens, Greece.
Ann Rheum Dis. 2003 Sep;62(9):795-8. doi: 10.1136/ard.62.9.795.
Despite the development of new modalities, cyclophosphamide (CYC) remains the preferred initial treatment for severe proliferative lupus nephritis. Controversies continue about the best route, dosage, and duration of CYC treatment. For recalcitrant disease, new immunosuppressive and immunomodulating agents, immunoablative high dose CYC, nucleoside analogues, apheresis, and the biological response modifiers can be considered.
尽管有了新的治疗方法，但环磷酰胺（CYC）仍然是重度增殖性狼疮性肾炎的首选初始治疗药物。关于CYC治疗的最佳途径、剂量和疗程仍存在争议。对于难治性疾病，可以考虑使用新的免疫抑制和免疫调节药物、免疫清除大剂量CYC、核苷类似物、血浆置换以及生物反应调节剂。
