Rao P H, Cesarman G, Coleman M, Acaron S, Verma R S
Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
Acta Haematol. 1992;88(4):201-3. doi: 10.1159/000204687.
A 27-year-old male developed massive generalized lymphadenopathy with chronic myelomonocytic leukemia (CMML) presenting as extramedullary blast crisis mimicking a lymphocytic lymphoma. On presentation, a consistent chromosomal abnormality involving chromosomes 8 and 13, i.e. 46,XY,t(8;13) (q11;p11), was present in lymph node tissue, bone marrow and unstimulated peripheral blood. The appearance of trisomy 21 in addition to the presence of the original cytogenetic abnormality is simply regarded as clonal evolution, i.e. 47,XY,t(8;13)(q11;p11),+21. The importance of the cytogenetics lies in finding the same abnormality in bone marrow and lymph node, adding evidence that the immunologically similar cells in the two sites have arisen from a common progenitor cell. To our knowledge, this novel chromosomal abnormality has not been reported in association with a unique case.
一名27岁男性患慢性粒单核细胞白血病（CMML）并出现广泛性淋巴结肿大，表现为髓外原始细胞危象，酷似淋巴细胞淋巴瘤。初诊时，淋巴结组织、骨髓和未受刺激的外周血中均存在涉及8号和13号染色体的一致染色体异常，即46,XY,t(8;13)(q11;p11)。除了原始细胞遗传学异常外，21号染色体三体的出现被简单视为克隆进化，即47,XY,t(8;13)(q11;p11),+21。细胞遗传学的重要性在于在骨髓和淋巴结中发现相同的异常，这进一步证明了两个部位免疫相似的细胞来源于共同的祖细胞。据我们所知，这种新的染色体异常尚未与独特病例相关联的报道。
