Jefferson J Ashley, Couser William G
University of Washington, Seattle, USA.
Semin Nephrol. 2003 Jul;23(4):400-5. doi: 10.1016/s0270-9295(03)00055-x.
Membranous nephropathy (MN) most commonly is idiopathic, but secondary causes are common in children and in older adults. The most common secondary causes of MN in industrialized countries include malignancy and systemic lupus erythematosis. Infectious causes (hepatitis B, quartan malaria, schistosomiasis) remain the most common etiologies in endemic areas. In this article we describe the clinical approach to patients with MN associated with malignancy and other common secondary causes. Treatment of secondary MN generally targets the primary disease rather than the renal lesion.
膜性肾病（MN）最常见的是特发性的，但继发性病因在儿童和老年人中很常见。在工业化国家，MN最常见的继发性病因包括恶性肿瘤和系统性红斑狼疮。在流行地区，感染性病因（乙型肝炎、三日疟、血吸虫病）仍然是最常见的病因。在本文中，我们描述了针对与恶性肿瘤及其他常见继发性病因相关的MN患者的临床处理方法。继发性MN的治疗通常针对原发性疾病而非肾脏病变。
