Niederhofer Helmut
Child and Adolescent Psychiatry, Regional Hospital Bozen, I-39100 Bolzano, Italy.
Hum Psychopharmacol. 2003 Aug;18(6):489-92. doi: 10.1002/hup.511.
Medications such as clonidine have been shown to facilitate calming, to enhance frustration tolerance, and to reduce aggression in attention deficit disorder (ADD) patients. The use of buspirone was studied as an alternative because of its longer excretion half-life, decreased sedative side effects and more selective binding profile.
Eight psychiatric outpatients diagnosed with ADD were rated at baseline and while taking buspirone to determine its efficacy as a treatment for ADD. Comparisons of Wender-Utah ratings within subject were used to measure behavioural changes in the subjects.
During buspirone treatment, the patients' mean scores improved significantly overall and in hyperactivity, inattention and immaturity factors.
This preliminary study indicates that buspirone might be a beneficial and useful treatment of ADD, reducing hyperactive behaviours and enabling greater attentional ability with minimal side effects.
已证明可乐定等药物有助于使注意力缺陷障碍（ADD）患者平静下来、增强挫折耐受力并减少攻击性。由于丁螺环酮的排泄半衰期更长、镇静副作用减少且结合谱更具选择性，因此对其使用进行了研究。
对八名被诊断为ADD的精神科门诊患者在基线时以及服用丁螺环酮期间进行评分，以确定其作为ADD治疗方法的疗效。采用受试者内Wender-Utah评分比较来测量受试者的行为变化。
在丁螺环酮治疗期间，患者的平均得分在总体上以及多动、注意力不集中和不成熟因素方面均有显著改善。
这项初步研究表明，丁螺环酮可能是一种治疗ADD的有益且有效的方法，可减少多动行为并在副作用最小的情况下提高注意力。
