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[超声引导下细针穿刺活检结果与组织学检查结果在乳腺门诊女性乳腺局灶性病变评估中的兼容性]

[Compatibility of the results of ultrasound-guided fine needle aspiration biopsy with the histological findings in assessment of focal breast lesions among woman attending the outpatient breast clinic].

作者信息

Lorek Andrzej, Wodołazski Anatol

机构信息

Przyszpitalnej Poradni Chorób Piersi Powiatowego Szpitala Nr 1 w Bedzinie.

出版信息

Wiad Lek. 2003;56(3-4):127-31.

PMID:12923957
Abstract

Continuous increase of morbidity and mortality rate due to breast cancer has led to development of new diagnostic methods that are aimed at detecting neoplastic and preneoplastic lesions in their early, yet asymptomatic stages. Development of modern imaging techniques (ultrasonography, mammography, magnetic resonance) and invasive diagnostic procedures (fine needle aspiration biopsy, core needle biopsy, stereotactically guided biopsy) allows to detect lesions not exceeding 1 cm in diameter, and therefore may provide a complete cure. The aim of this study was to estimate diagnostic usefulness of ultrasound-guided fine needle aspiration biopsy in detecting benign breast dysplasia (with and without proliferation of ductal epithelial cells), benign neoplastic lesions and breast cancer, as well as to determine compatibility between US-guided FNAB results and subsequent histological findings. The study group consisted of 213 female patients. The obtained results were subject for statistical analyses that revealed a high degree of compatibility between US-guided FNAB and histological results (93.6-95.5%), and also confirmed high sensitivity of US-guided FNAB. This method has proved to be an efficient diagnostic tool for early detection of benign breast dysplasia, benign neoplasms and breast cancer, making early surgical treatment possible in most cases and permitting omission of an intra-operative histological examination.

摘要

乳腺癌导致的发病率和死亡率持续上升,促使人们开发新的诊断方法,旨在在肿瘤和癌前病变的早期无症状阶段进行检测。现代成像技术(超声检查、乳腺X线摄影、磁共振成像)和侵入性诊断程序(细针穿刺活检、粗针穿刺活检、立体定向引导活检)的发展使得能够检测直径不超过1厘米的病变,因此可能实现完全治愈。本研究的目的是评估超声引导下细针穿刺活检在检测乳腺良性发育异常(伴有或不伴有导管上皮细胞增殖)、良性肿瘤性病变和乳腺癌方面的诊断效用,并确定超声引导下细针穿刺活检结果与后续组织学结果之间的一致性。研究组由213名女性患者组成。对所得结果进行统计分析,结果显示超声引导下细针穿刺活检与组织学结果之间具有高度一致性(93.6 - 95.5%),同时也证实了超声引导下细针穿刺活检具有较高的敏感性。该方法已被证明是早期检测乳腺良性发育异常、良性肿瘤和乳腺癌的有效诊断工具,在大多数情况下可实现早期手术治疗,并可省略术中组织学检查。

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