Soumarová R, Kalábová R, Perková H
Klinika komplexní onkologické péce-oddĕlení radiacní onkologie, Masarykův onkologický ústav, Brno.
Cas Lek Cesk. 2003;142 Suppl 1:51-2.
Vulvar carcinoma belongs between the less frequent gynaecologic malignancies. Despite to the low morbidity its mortality is high. The reason is locally advanced disease at the time of diagnosis. Radical surgery is mutilating for patient. Radiotherapy was not considered as a standard treatment. Recently, due to technical improvement, mega-voltage facilities and knowledge of radiobiology, radiotherapy has become a part of standard treatment modalities. It plays an important role in the curative, adjuvant and palliative treatment. Concomitant chemoradiotherapy has been used since the eighties of the last century to improve results and reduce extent of surgery in locally advanced vulvar carcinomas. Results show that concomitant chemoradiotherapy is a method of choice in the treatment of locally advanced or recurrent disease. Additional studies are necessary to determine the specific categories of patients who would benefit most from concomitant chemoradiotherapy.
外阴癌属于较少见的妇科恶性肿瘤。尽管发病率较低，但其死亡率却很高。原因是在诊断时疾病已处于局部晚期。根治性手术对患者有致残性。放疗过去未被视为标准治疗方法。近来，由于技术进步、兆伏级设备以及放射生物学知识的发展，放疗已成为标准治疗方式的一部分。它在根治性、辅助性和姑息性治疗中都发挥着重要作用。从上世纪八十年代起，同步放化疗就被用于改善局部晚期外阴癌的治疗效果并缩小手术范围。结果表明，同步放化疗是治疗局部晚期或复发性疾病的首选方法。还需要进一步研究来确定最能从同步放化疗中获益的特定患者类别。
