Sýkorová M, Havránek E
Katedra farmaceutickej analýzy a nukleárnej farmácie Farmaceutickej fakulty UK, Bratislava.
Ceska Slov Farm. 2003 Jul;52(4):203-6.
X-ray fluorescence analysis (XRF) has been employed for the identification and determination of elements with Z > 18. In pharmacy, it can be used to determine the content of elements in drugs and pharmaceutical auxiliary substances. The method makes it possible to distinguish heavy metals in the tests of purity of drugs. It can also be used to verify the origin of the raw material or drug on the basis of its elemental composition. The present paper is concerned with the preparation of samples of pharmaceutical auxiliary substances for the determination of the content of the elements Fe, Cu, Zn, and Pb by the XRF method with the use of a radionuclide source of 238Pu. For the determination of the content of elements, three kinds of standards were prepared aiming to remove the effect of absorption properties of the sample. The results with statistical evaluations of precision of measurement are tabulated. The study carried out an analysis of 7 samples of fillers, 3 samples of gelatine, 2 samples of SILOXID, and 1 sample of AEROSIL.
X射线荧光分析（XRF）已用于识别和测定原子序数Z>18的元素。在药学领域，它可用于测定药物和药用辅料中的元素含量。该方法能够在药物纯度检测中鉴别重金属。它还可根据原料或药物的元素组成来验证其来源。本文涉及使用238Pu放射性核素源，通过XRF法测定药用辅料中Fe、Cu、Zn和Pb元素含量时样品的制备。为测定元素含量，制备了三种标准品，旨在消除样品吸收特性的影响。列出了测量精度统计评估的结果。该研究对7个填充剂样品、3个明胶样品、2个SILOXID样品和1个AEROSIL样品进行了分析。
