单中心和多中心Castleman病中镓摄取缺失。

Absence of gallium uptake in unicentric and multicentric Castleman's disease.

作者信息

Okamoto Isamu, Iyonaga Kazuhiro, Fujii Kazuhiko, Mori Takeshi, Yoshioka Masakazu, Kohrogi Hirotsugu, Matsumoto Mitsuhiro, Suga Moritaka

机构信息

Department of Respiratory Medicine, Graduate School of Medical Science Kumamoto University, Kumamoto.

出版信息

Intern Med. 2003 Aug;42(8):735-9. doi: 10.2169/internalmedicine.42.735.

DOI:10.2169/internalmedicine.42.735

PMID:12924503

Abstract

Castleman's disease is a rare and poorly understood condition involving lymph nodes at various sites, predominantly in the mediastinum. Individuals with this disease often present with lymphadenopathy and general symptoms suggestive of lymphomatous disease, and they are at risk of developing malignant lymphoma. It is thus important to distinguish Castleman's disease from other lymphoproliferative disorders. 67Ga scintigraphy is a non-invasive and practical diagnostic tool for the investigation of patients with lymphoproliferative disorders. However, the value of this technique for the diagnosis of Castleman's disease is not clear. Here, we describe five consecutive patients with various types of Castleman's disease and show that none of these individuals exhibited 67Ga uptake. Our results suggest the potential value of 67Ga scintigraphy in both the diagnosis and management of Castleman's disease.

摘要

卡斯特曼病是一种罕见且了解甚少的疾病，累及身体各个部位的淋巴结，主要位于纵隔。患有这种疾病的个体常表现为淋巴结病以及提示淋巴瘤疾病的全身症状，并且有发展为恶性淋巴瘤的风险。因此，将卡斯特曼病与其他淋巴增殖性疾病区分开来很重要。67Ga闪烁扫描是一种用于研究淋巴增殖性疾病患者的非侵入性实用诊断工具。然而，这项技术对卡斯特曼病的诊断价值尚不清楚。在此，我们描述了连续5例患有不同类型卡斯特曼病的患者，并表明这些个体均未表现出67Ga摄取。我们的结果提示67Ga闪烁扫描在卡斯特曼病的诊断和管理中具有潜在价值。