肝素诱导的体外低密度脂蛋白沉淀。

Heparin-induced extracorporeal low-density lipoprotein precipitation.

作者信息

Mellwig Klaus-Peter

机构信息

Department of Cardiology, North Rhine-Westphalia Heart and Diabetes Center, University Hospital, Ruhr University Bochum, Bad Oeynhausen, Germany.

出版信息

Ther Apher Dial. 2003 Jun;7(3):365-9. doi: 10.1046/j.1526-0968.2003.00051.x.

DOI:10.1046/j.1526-0968.2003.00051.x

PMID:12924614

Abstract

Heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) is a selective and careful apheresis procedure. Through the application of heparin and lowering the pH value, lipoproteins and fibrinogen are reduced by 50-60%. In addition, adhesion molecules (ICAM-1, VCAM-1, p-selectin) which play a key role in the development and progression of atherosclerosis, are also markedly reduced. A PET scan performed 20 h after LDL apheresis shows the improvement of coronary vasodilation capacity. This is supposed to be mainly due to the marked reduction of LDL cholesterol and fibrinogen with consecutive improvement of endothelial dysfunction and rheology.

摘要

肝素诱导的体外低密度脂蛋白（LDL）沉淀法（HELP）是一种选择性且精细的血液成分分离程序。通过应用肝素并降低pH值，脂蛋白和纤维蛋白原可减少50 - 60%。此外，在动脉粥样硬化的发生和发展中起关键作用的黏附分子（ICAM - 1、VCAM - 1、p - 选择素）也会显著减少。LDL血液成分分离术后20小时进行的PET扫描显示冠状动脉舒张能力有所改善。这被认为主要是由于LDL胆固醇和纤维蛋白原显著减少，继而内皮功能障碍和血液流变学得到改善。