Defilippi Carlos
Program of Physiology and Biophysics, School of Medicine, University of Chile, Santiago, Chile.
Dig Dis Sci. 2003 Aug;48(8):1482-6. doi: 10.1023/a:1024799303676.
The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min were performed and motility recorded by means of infused catheters. Nonstatistically significant differences were observed between frequency of contractions during infusion of 0.5 (4.1 +/- 1.6 cpm) and 2 kcal/min (5.3 +/- 1.5 cpm) compared to control (4.3 +/- 1.9 cpm). With 4 kcal/min a significant decrease of frequency (2.7 +/- 0.9 cpm) was observed. A similar finding was observed for amplitude of contrations. With 0.5 kcal/min fasting cyclic activity was still present, but the numbers of phase III were significantly reduced, associated with an increased duration of phase II. With higher caloric loads cyclic fasting activity was replaced by marked variations of frequency, following a cyclic pattern. A lower threshold for mechanisms switching the fasting to fed state was observed, compared to those controlling frequency and amplitude.
营养素对小肠蠕动的影响存在争议。我们的目的是分析十二指肠内输注热量负荷递增的营养素混合物对肠道蠕动的影响。研究在装有十二指肠插管的犬身上进行。分别以等渗溶液、0.5、2和4千卡/分钟的速度进行输注，并通过插入的导管记录蠕动情况。与对照组（4.3±1.9次/分钟）相比，在输注0.5（4.1±1.6次/分钟）和2千卡/分钟（5.3±1.5次/分钟）时，收缩频率无统计学显著差异。当输注速度为4千卡/分钟时，频率显著降低（2.7±0.9次/分钟）。收缩幅度也有类似发现。输注0.5千卡/分钟时，空腹时的周期性活动仍然存在，但第三相的次数显著减少，同时第二相的持续时间延长。热量负荷更高时，空腹时的周期性活动被频率的显著变化所取代，呈现出周期性模式。与控制频率和幅度的机制相比，观察到将空腹状态转换为进食状态的机制阈值更低。
