von Schönfeld J, Evans D F, Renzing K, Castillo F D, Wingate D L
Gastrointestinal Science Research Unit, London Hospital Medical College, UK.
Dig Dis Sci. 1998 Feb;43(2):265-9. doi: 10.1023/a:1018885717947.
Previous animal studies have shown that the nature and duration of postprandial motility in the small bowel depend both on the caloric load and the chemical composition of a meal. It is not clear whether this is also true for the human small bowel. Therefore we investigated the motor activity of the human small bowel in response to nutrient liquids of different caloric value and different chemical composition. Ten human volunteers underwent three separate, 24-hr ambulatory manometry studies. They drank water, a pure glucose solution, and Intralipid 10% in volumes of both 300 and 600 ml. The caloric value of the nutrient liquids was 330 and 660 kcal, respectively. Records were analyzed visually for the reappearance of phase III of the MMC after ingestion of a test liquid, and a validated computer program calculated the incidence and amplitude of contractions during the postprandial period. Neither duration of the postprandial interval nor the mean incidence or mean amplitude of contractions were different between the fat and the carbohydrate solutions, but phase III reappeared significantly later after ingestion of the nutrient liquids than after water (P = 0.0002). Duration of the postprandial interval also depended on the volume or the caloric load of a liquid meal (P = 0.0012). Mean incidence of contractions tended to be higher after ingestion of nutrient liquids than after water (P = 0.059). We conclude that in ambulant subjects, small bowel motor activity in response to chemically diverse liquid meals is remarkably uniform. This is true for the duration of the postprandial motor activity, as well as the incidence and amplitude of contractions during that period. The caloric value of a liquid meal, however, regulates the duration of the postprandial interval in the human small bowel.
先前的动物研究表明，小肠餐后运动的性质和持续时间既取决于热量负荷，也取决于膳食的化学成分。目前尚不清楚这对人类小肠是否也成立。因此，我们研究了人类小肠对不同热量值和不同化学成分的营养液的运动反应。10名人类志愿者接受了3次独立的24小时动态测压研究。他们分别饮用了300毫升和600毫升的水、纯葡萄糖溶液和10%的英脱利匹特（Intralipid）。这些营养液的热量值分别为330千卡和660千卡。对记录进行视觉分析，以观察摄入测试液体后MMC第三相的再次出现情况，并且一个经过验证的计算机程序计算了餐后期间收缩的发生率和幅度。脂肪溶液和碳水化合物溶液之间，餐后间隔的持续时间、收缩的平均发生率或平均幅度均无差异，但摄入营养液后第三相比摄入水后明显延迟出现（P = 0.0002）。餐后间隔的持续时间也取决于液体膳食的体积或热量负荷（P = 0.0012）。摄入营养液后收缩的平均发生率往往高于摄入水后（P = 0.059）。我们得出结论，在活动的受试者中，小肠对化学组成不同的液体膳食的运动反应非常一致。这在餐后运动活动的持续时间以及该期间收缩的发生率和幅度方面均是如此。然而，液体膳食的热量值调节了人类小肠餐后间隔的持续时间。
