Ioannidou S, Tassios P T, Zachariadou L, Salem Z, Kanelopoulou M, Kanavaki S, Chronopoulou G, Petropoulou N, Foustoukou M, Pangalis A, Trikka-Graphakos E, Papafraggas E, Vatopoulos A C
Department of Hygiene and Epidemiology, Medical School, Athens University, 115 27 Athens (Goudi), Greece.
Clin Microbiol Infect. 2003 Jul;9(7):704-7. doi: 10.1046/j.1469-0691.2003.00572.x.
The susceptibilities to macrolides and telithromycin of 161 Streptococcus pyogenes and 145 Streptococcus pyogenes strains, consecutively isolated from five Greek hospitals, were determined by Etest. Moreover, mechanisms of resistance to macrolides were phenotypically and genetically determined by double disk induction test and PCR, respectively. Of the S. pneumoniae and S. pyogenes isolates, 42.8% and 30.8%, respectively, were found to be resistant to erythromycin. Of the erythromycin-resistant S. pneumoniae and S. pyogenes isolates, 57.5% and 59.5%, respectively, displayed the M phenotype and harbored the mefA/E gene. Telithromycin was found to be more active than both erythromycin and clarithromycin against both species, with considerably lower MIC50 and MIC90 values.
采用Etest法测定了从希腊五家医院连续分离出的161株化脓性链球菌和145株化脓性链球菌对大环内酯类药物和泰利霉素的敏感性。此外，分别通过双纸片诱导试验和PCR从表型和基因水平确定了对大环内酯类药物的耐药机制。在肺炎链球菌和化脓性链球菌分离株中，分别有42.8%和30.8%被发现对红霉素耐药。在对红霉素耐药的肺炎链球菌和化脓性链球菌分离株中，分别有57.5%和59.5%表现为M表型并携带mefA/E基因。结果发现，泰利霉素对这两种菌的活性均高于红霉素和克拉霉素，其MIC50和MIC90值显著更低。
