Froemke Robert C, Li Cheng-yu, Dan Yang
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Neuron. 2003 Aug 14;39(4):579-81. doi: 10.1016/s0896-6273(03)00503-8.
In this issue of Neuron, Sjöström et al. provide evidence for a novel presynaptic mechanism for coincidence detection in induction of timing-dependent LTD. In their scheme, simultaneous activation of presynaptic NMDA receptors and CB1 endocannabinoid receptors induces a long-lasting reduction in presynaptic transmitter release.
在本期《神经元》杂志中，舍斯特伦等人提供了证据，证明在依赖时间的长时程抑制（LTD）诱导过程中，存在一种用于同步检测的新型突触前机制。在他们的机制中，突触前N-甲基-D-天冬氨酸（NMDA）受体和大麻素1型（CB1）内源性大麻素受体的同时激活会导致突触前递质释放的长期减少。
