脓毒症之谜。
The enigma of sepsis.
作者信息
Riedemann Niels C, Guo Ren-Feng, Ward Peter A
机构信息
Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109-0602, USA.
出版信息
J Clin Invest. 2003 Aug;112(4):460-7. doi: 10.1172/JCI19523.
Abstract
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.
摘要
脓毒症仍然是发病和死亡的一个严重原因，并且该疾病的病理生理学尚不清楚。脓毒症临床表现的定义一直在不断演变。本综述讨论了寻找有效的治疗干预措施、脓毒症转化研究中的障碍以及当前临床试验中正在研发的新疗法。
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