一个赋予小鼠对肺炎链球菌感染易感性的主要基因座。
A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
作者信息
Denny Paul, Hopes Elaine, Gingles Neill, Broman Karl W, McPheat William, Morten John, Alexander Janet, Andrew Peter W, Brown Steve D M
机构信息
MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK.
出版信息
Mamm Genome. 2003 Jul;14(7):448-53. doi: 10.1007/s00335-002-2261-9.
PMID:12925893
Abstract
We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.
摘要
我们研究了小鼠对肺炎链球菌感染易感性的遗传学。通过对抗性BALB/cO1aHsd和易感CBA/CaO1aHsd品系杂交产生的F(2)代进行连锁分析，我们得以定位一个控制菌血症发展及鼻内感染后存活情况的主要基因座。
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