肺炎链球菌菌毛亚基可保护小鼠免受致命攻击。
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
作者信息
Gianfaldoni Claudia, Censini Stefano, Hilleringmann Markus, Moschioni Monica, Facciotti Claudia, Pansegrau Werner, Masignani Vega, Covacci Antonello, Rappuoli Rino, Barocchi Michèle Anne, Ruggiero Paolo
机构信息
Novartis Vaccines and Diagnostics s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy.
出版信息
Infect Immun. 2007 Feb;75(2):1059-62. doi: 10.1128/IAI.01400-06. Epub 2006 Dec 4.
Abstract
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
摘要
肺炎链球菌是全球主要的公共卫生威胁。最近发现这种病原体具有菌毛，这促使我们在小鼠腹腔感染模型中研究其保护能力。用重组菌毛亚基进行主动和被动免疫均可提供针对肺炎链球菌4型菌株TIGR4致死性攻击的保护作用。
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