Härtig Wolfgang, Riedel Anett, Grosche Jens, Edwards Robert H, Fremeau Robert T, Harkany Tibor, Brauer Kurt, Arendt Thomas
Paul Flechsig Institute for Brain Research, University of Leipzig, D-04109 Leipzig, Germany.
J Comp Neurol. 2003 Oct 6;465(1):1-10. doi: 10.1002/cne.10789.
The caudomedial shell of the rat nucleus accumbens exhibits inhomogeneous distribution patterns of the vesicular glutamate transporters 1 (VGLUT1) and 2 (VGLUT2). This paper focuses on the question of whether patterns of VGLUT1 and VGLUT2 correspond to cytoarchitectonically and cytochemically defined subterritories of the caudomedial shell region. VGLUT2 was shown to be coexpressed with calretinin in the dense axonal plexus known to emanate from the paraventricular thalamic nucleus. In regions termed corridors, which are spared by this paraventricular thalamic innervation, axonal terminals were found to be clustered and VGLUT1-immunoreactive. It is assumed that these fibers originate in the prelimbic cortex and/or in the parvicellular basal amygdaloid nucleus known to project to accumbal shell components. Our findings confirm the existence of two well-separated neuronal circuits in the caudomedial shell that are dominated by two different excitatory input systems originating from either thalamic, cortical, or cortex-like amygdaloid sources. The large lateral corridors-which resemble the accumbal core not only in respect to their VGLUT1 immunolabeling but also concerning their content of calbindin-positive cells-may represent a component of the anatomically weakly defined accumbal shore region.
大鼠伏隔核的尾内侧壳区呈现出囊泡型谷氨酸转运体1（VGLUT1）和2（VGLUT2）的不均匀分布模式。本文聚焦于VGLUT1和VGLUT2的模式是否与尾内侧壳区细胞构筑学和细胞化学定义的亚区域相对应这一问题。研究表明，VGLUT2与钙视网膜蛋白在已知起源于室旁丘脑核的密集轴突丛中共表达。在被这种室旁丘脑神经支配所遗漏的区域，即所谓的“通道”区域，发现轴突终末聚集且呈VGLUT1免疫反应性。据推测，这些纤维起源于已知投射到伏隔核壳区成分的前边缘皮层和/或小细胞基底杏仁核。我们的研究结果证实，在尾内侧壳区存在两个分离良好的神经元回路，它们由分别起源于丘脑、皮层或类似皮层的杏仁核来源的两种不同兴奋性输入系统主导。较大的外侧通道——不仅在VGLUT1免疫标记方面，而且在钙结合蛋白阳性细胞含量方面都类似于伏隔核核心——可能代表了解剖学上定义不明确的伏隔核边缘区的一个组成部分。
