Raffetto Nicola, Tombolini Vincenzo, Santarelli Mario, Valeriani Maurizio, Galla Domenico A, Enrici Riccardo Maurizi
Chair of Radiotherapy, University of L'Aquila, Department of Experimental Medicine, Radiotherapy Unit of S. Salvatore Hospital, L'Aquila, Italy.
Anticancer Res. 2003 May-Jun;23(3C):3105-8.
To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes.
Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed with a combination of chemotherapy and radiotherapy, seven out of these with concomitant radio-chemotherapy and four with neo-adjuvant chemotherapy. Nine patients were submitted to radiotherapy alone. The total dose of radiation therapy ranged from 30 Gy to 70 Gy.
The median follow-up was 6 months (range 2-70 months). The 5-year overall and disease-free survival for the entire cohort was 20%. The outcomes included 6 complete response (CR), 10 partial response (PR) and 4 no change (NC). Patients with one site of recurrence and size of lesion < or = 3 cm were long survivors and disease-free at 5 years; all these women received a total dose of radiation therapy > or = 6480 cGy.
We emphasize the importance of the number, site and diameter of recurrences as prognostic indicators; the outcomes of these patients were also affected by the total dose of radiation therapy.
评估单纯放疗或联合化疗在复发性外阴癌治疗中的作用，重点关注预后因素和治疗结果。
回顾性分析20例局部区域复发的外阴癌患者。11例患者接受了化疗和放疗联合治疗，其中7例接受同步放化疗，4例接受新辅助化疗。9例患者仅接受放疗。放射治疗的总剂量为30Gy至70Gy。
中位随访时间为6个月（范围2 - 70个月）。整个队列的5年总生存率和无病生存率为20%。治疗结果包括6例完全缓解（CR）、10例部分缓解（PR）和4例病情无变化（NC）。复发部位为一处且病灶大小≤3cm的患者为长期生存者，5年无病生存；所有这些女性接受的放射治疗总剂量≥6480cGy。
我们强调复发的数量、部位和直径作为预后指标的重要性；这些患者的治疗结果也受到放射治疗总剂量的影响。
