[肺癌患者术中放疗及辅助化疗的并发症]
[Complications of intraoperative radiotherapy and adjuvant chemotherapy in patients with lung cancer].
作者信息
Zyrianov B N, Zav'ialov A A, Miller S V, Khodkevich B S, Kolomiets S A, Evtushenko V A, Cheremisina O V, Rudyk Iu V, Tropin S V
机构信息
Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.
出版信息
Vopr Onkol. 2003;49(3):370-2.
A high single dose of radiation can be delivered precisely to tumor or regional metastasis area by means of intraoperative radiation therapy (IORT). A program of combined treatment including radical IORT, postoperative distant gamma-therapy and adjuvant polychemotherapy with cisplatin and etoposide has been developed at the Center. Treatment was given to 43 patients with stage III lung cancer. Complications were reported in 23.3 +/- 6.0%. Prophylactic methods have been worked out to minimize IORT--related postoperative complications. The postoperative lethality rate was 2.3 +/- 1.4%. No program-related hazards have been observed. Complications from adjuvant polychemotherapy were moderate.
通过术中放射治疗（IORT），可以将高单次剂量的辐射精确地传递到肿瘤或区域转移部位。该中心已经制定了一个综合治疗方案，包括根治性IORT、术后远距离伽马治疗以及顺铂和依托泊苷辅助多药化疗。对43例III期肺癌患者进行了治疗。据报道，并发症发生率为23.3±6.0%。已经制定了预防方法，以尽量减少与IORT相关的术后并发症。术后死亡率为2.3±1.4%。未观察到与治疗方案相关的风险。辅助多药化疗的并发症为中度。
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