钆喷酸葡胺-（BOM）4的制备及其体外评价；一种新型血管造影磁共振成像造影剂。
Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent.
作者信息
Hovland Ragnar, Aasen Arne J, Klaveness Jo
机构信息
Department of Medicinal Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1155, Blindern, N-0318 Oslo, Norway.
出版信息
Org Biomol Chem. 2003 May 21;1(10):1707-10. doi: 10.1039/b301944f.
A novel Gd(III) complex, GdDOTA-(BOM)4, has been prepared by a simple three-step procedure. The complex showed high T1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T1-relaxivity in plasma, 67.4 s-1 mM-1 (20 MHz, 37 degrees C), makes it a promising candidate for angiographic applications of MRI.
一种新型的钆（III）配合物GdDOTA-(BOM)4已通过简单的三步程序制备而成。该配合物在血清白蛋白溶液、血液和血浆中表现出高的T1弛豫率值，这是由于其对血清白蛋白具有高亲和力。其在血浆中的T1弛豫率为67.4 s-1 mM-1（20 MHz，37摄氏度），使其成为磁共振成像血管造影应用的一个有前景的候选物。
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