Shimada Yuhei, Kiyosawa Motohiro, Nariai Tadashi, Oda Keiichi, Toyama Hinako, Ono Kenichirou, Senda Michio, Ishiwata Kiichi
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, Tokyo 172-0022, Japan.
Am J Vet Res. 2003 Aug;64(8):999-1002. doi: 10.2460/ajvr.2003.64.999.
To map central benzodiazepine receptors (BZRs) in the brain of cats by use of positron-emission tomography (PET) and [11C]flumazenil.
6 male cats that weighed between 2.0 and 3.6 kg.
Brain images obtained by PET evaluation of [11C]flumazenil were superimposed on T2-weighted magnetic-resonance imaging (MRI) scans of the same cats. Detailed anatomic regions, such as the cerebral cortex, striatum, thalamus, midbrain, and cerebellum, on the PET images were evident by PET-MRI registration. Regional binding of [11C]flumazenil to BZRs was quantitatively measured by use of a model with 2 tissue compartments and 4 variables.
The highest value for distribution volume was observed in the cerebral cortex, and the lowest value was found in the midbrain of cats.
Binding of [11C]flumazenil to BZRs in the brain of cats can be quantitatively measured by use of PET with the aid of PET-MRI registration. It is difficult to diagnose changes in these neuroreceptors within the field of current veterinary science. In the future, PET should prove useful for investigating and diagnosing brain disorders in animals in clinical settings.
通过正电子发射断层扫描（PET）和[11C]氟马西尼来绘制猫脑中的中枢苯二氮䓬受体（BZR）分布图。
6只体重在2.0至3.6千克之间的雄性猫。
通过PET评估[11C]氟马西尼获得的脑部图像被叠加到同一只猫的T2加权磁共振成像（MRI）扫描图像上。通过PET-MRI配准，PET图像上的详细解剖区域，如大脑皮层、纹状体、丘脑、中脑和小脑清晰可见。使用具有2个组织隔室和4个变量的模型对[11C]氟马西尼与BZR的区域结合进行定量测量。
在猫的大脑皮层中观察到分布容积的最高值，在中脑中发现最低值。
借助PET-MRI配准，使用PET可对猫脑中[11C]氟马西尼与BZR的结合进行定量测量。在当前兽医学领域，诊断这些神经受体的变化很困难。未来，PET在临床环境中对动物脑部疾病的研究和诊断应会证明是有用的。
