Sachithanandan A, Gleadhill I, Alexander H D, Morris T C M
Department of Cardiac Surgery, Royal Victoria Hospital, Belfast BT12 6BA.
Ir Med J. 2003 Jun;96(6):181-2.
Philadelphia chromosome negative and bcr/abl negative chronic myeloid leukaemia (CML) is an uncommon atypical CML. We describe a patient with this disorder who experienced an acute blastic transformation that resulted in rapid splenic enlargement and subsequent atraumatic splenic rupture. Clinically, spontaneous splenic rupture may be a difficult diagnosis to make and this case highlights the importance of considering atraumatic splenic rupture as a cause for unexplained abdominal pain in a patient with a haematological malignancy.
费城染色体阴性且bcr/abl阴性的慢性髓性白血病（CML）是一种罕见的非典型慢性髓性白血病。我们描述了一名患有这种疾病的患者，该患者经历了急性原始细胞转化，导致脾脏迅速肿大，随后发生非创伤性脾破裂。临床上，自发性脾破裂可能难以诊断，该病例突出了在血液系统恶性肿瘤患者中，将非创伤性脾破裂视为不明原因腹痛病因的重要性。
