Dergunov A D
Biull Eksp Biol Med. 1992 Dec;114(12):598-600.
The relationship between the concentration of serum amyloid protein (SAP) isolated from human serum and the parameters of the protein elution during gel-filtration and alos with the efficiency of Ca(2+)-dependent SAP binding with sepharose 4B was studied. The dissociation of the SAP oligomeric form in solution and the interaction of the protein with human serum albumin with fully reduced S--S bridges due to the introduction of the additional hydrophobic surface was shown. Apoprotein E isolated from human plasma very-low-density lipoproteins replaced SAP in the complex with albumin.
研究了从人血清中分离出的血清淀粉样蛋白（SAP）浓度与凝胶过滤过程中蛋白质洗脱参数以及Ca(2+)依赖性SAP与琼脂糖4B结合效率之间的关系。结果表明，溶液中SAP寡聚体形式的解离以及由于引入额外疏水表面导致蛋白质与具有完全还原S-S桥的人血清白蛋白之间的相互作用。从人血浆极低密度脂蛋白中分离出的载脂蛋白E取代了复合物中与白蛋白结合的SAP。
