Molchanova I V, Belokrylov G A, Popova O Ia, Kalikhevich V N
Biull Eksp Biol Med. 1992 Dec;114(12):631-3.
Immunostimulating properties of cholecystokinin octapeptide (CCK-8) were evaluated in experiments on adult normal and thymectomized mice, in vitro. It was shown that CCK-8 stimulates IgM-PFC production to SRBC, but does not change the immune response to Vi-antigen. CCK-8 increases the number of Thy-I+ spleen T cells and restores thymus-dependent immune response in thymectomized mice. CCK-8 has no effect on neutrophil phagocytosis activity in vitro. The immunostimulating activity of CCK-8 is related mainly to C-terminal fragment (identical to pentagastrin tetrapeptide) since the N-terminal CCK-8 tetrapeptide displays negligible effect in all tests.
在体外对成年正常小鼠和胸腺切除小鼠进行的实验中，评估了胆囊收缩素八肽（CCK-8）的免疫刺激特性。结果表明，CCK-8刺激对绵羊红细胞（SRBC）的IgM-空斑形成细胞（PFC）产生，但不改变对Vi抗原的免疫反应。CCK-8增加了Thy-1⁺脾脏T细胞的数量，并恢复了胸腺切除小鼠的胸腺依赖性免疫反应。CCK-8在体外对中性粒细胞吞噬活性没有影响。CCK-8的免疫刺激活性主要与C末端片段（与五肽胃泌素四肽相同）有关，因为N末端CCK-8四肽在所有测试中显示出可忽略不计的作用。
