Norra Christine, Skobel Erik, Breuer Christian, Haase Gerhard, Hanrath Peter, Hoff Paul
Department of Psychiatry and Psychotherapy, University Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Eur Psychiatry. 2003 Aug;18(5):262-3. doi: 10.1016/s0924-9338(03)00091-9.
Tuberculosis (TB) increasingly appears in a multidrug-resistant form (MDR-TB) in Europe, too. Treatment remains difficult due to various side effects of the multi-drug-regimens. Ciprofloxacin is widely used as one of the few TB-second-line drugs. We report on the course of a ciprofloxacin-induced acute psychosis in a patient with MDR(isoniazid, streptomycin)-TB which resolved after cessation of ciprofloxacin treatment and introduction of a novel oxazolidone. Careful treatment considerations particularly in patients with additional predisposing factors to neuropsychiatric symptoms are recommended in the potentially dangerous MDR-TB, thus creating an enormous therapeutic challenge.
结核病（TB）在欧洲也越来越多地以耐多药形式（MDR-TB）出现。由于多药治疗方案的各种副作用，治疗仍然困难。环丙沙星作为少数几种结核病二线药物之一被广泛使用。我们报告了1例耐多药（异烟肼、链霉素）结核病患者发生环丙沙星诱发的急性精神病的病例，该病例在停用环丙沙星治疗并引入一种新型恶唑烷酮后病情得到缓解。在潜在危险的耐多药结核病中，建议谨慎考虑治疗方案，尤其是对于有神经精神症状附加易感因素的患者，因此这带来了巨大的治疗挑战。
