Simon O, Raibaut P, Faucher M, Sheik-Ismael S, Amarenco G
Service de rééducation neurologique et d'explorations périnéales, hôpital Rothschild, AP-HP, 33, boulevard de Picpus, 75571 Paris cedex 12, France.
Ann Readapt Med Phys. 2003 Jul;46(6):312-8. doi: 10.1016/s0168-6054(03)00104-1.
Use of botulinum toxin in headache is a recent method. More and more studies are dedicated to this method. However, despite the large number of published studies, results are contradictory. It is actually difficult to conclude that this therapy is effective or not due to the disparity of clinical studies. Nevertheless, some results are encouraging and studies with a large number of patients have to be done. Here, we take stock about pathophysiological data on the effect of botulinum toxin on pain. Then, we'll report a review of clinical studies available on literature.
肉毒杆菌毒素用于治疗头痛是一种新方法。越来越多的研究致力于此方法。然而，尽管已发表的研究数量众多，但结果相互矛盾。由于临床研究的差异，实际上很难得出这种疗法是否有效的结论。尽管如此，一些结果令人鼓舞，仍需开展大量患者的研究。在此，我们总结肉毒杆菌毒素对疼痛影响的病理生理数据。然后，我们将汇报对文献中现有临床研究的综述。
