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A型肉毒杆菌毒素在神经耳鼻喉科的应用

[Use of botulinum toxin type A in neuro-ORL].

作者信息

Périé S, Lacau St Guily J

机构信息

Service d'ORL et de chirurgie cervicofaciale, hôpital Tenon, 4, rue de la Chine, 75970 Paris cedex 20, France.

出版信息

Ann Readapt Med Phys. 2003 Jul;46(6):375-9. doi: 10.1016/s0168-6054(03)00127-2.

Abstract

Dystonia is the result of abnormal contractions of muscles, which may disturb activities between agonist and antagonist muscles. Since synchronization of laryngeal and masticatory muscles is highly necessary to allow opening and closure of the larynx or the mouth, expression of dystonia is especially exhibited. Focal laryngeal dystonia may disturb phonation, but also breathing or swallowing, which may be difficult to identify. In ORL, the botulinum toxin is used to treat focal dystonias, especially laryngeal (spamodic dysphonia being predominant) and oromandibular dystonias. Beside these indications, intracutaneous injections of botulinum toxin may be helpful in Frey's syndrome in patients with gustatory sweating; injections in the upper esophageal sphincter are also performed in cricopharyngeal dysphagia although this indication is mainly controversial.

摘要

肌张力障碍是肌肉异常收缩的结果,这可能会干扰主动肌和拮抗肌之间的活动。由于喉肌和咀嚼肌的同步对于喉或口的开合非常必要,因此肌张力障碍的表现尤为明显。局灶性喉肌张力障碍可能会干扰发声,也会影响呼吸或吞咽,这些情况可能难以识别。在耳鼻喉科,肉毒杆菌毒素用于治疗局灶性肌张力障碍,尤其是喉部(主要是痉挛性发音障碍)和口下颌肌张力障碍。除了这些适应症外,皮内注射肉毒杆菌毒素可能有助于治疗味觉性出汗患者的弗雷综合征;尽管这一适应症主要存在争议,但在上食管括约肌注射肉毒杆菌毒素也用于治疗环咽肌功能障碍引起的吞咽困难。

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