用纯化肉毒杆菌毒素治疗味觉性出汗综合征（Frey综合征）和“鳄鱼泪”（味觉性流泪）
Treatment of Frey's syndrome (gustatory sweating) and 'crocodile tears' (gustatory epiphora) with purified botulinum toxin.
作者信息
Hofmann R J
机构信息
Brown University School of Medicine, Providence, Rhode Island, USA.
出版信息
Ophthalmic Plast Reconstr Surg. 2000 Jul;16(4):289-91. doi: 10.1097/00002341-200007000-00007.
PURPOSE
To determine whether purified botulinum toxin might be as effective in the treatment of "crocodile tears" (gustatory epiphora) as it has been in the treatment of other hypersecretion syndromes such as Frey's syndrome (gustatory sweating).
METHODS
One patient with Frey's syndrome (gustatory sweating) was successfully treated with botulinum toxin. After this, two patients with chronic symptomatic crocodile tears (related to previous facial palsy) were treated with botulinum toxin injections into and around the lacrimal gland.
RESULTS
Both patients reported remarkable relief from symptoms and were observed to have no tearing while eating.
CONCLUSIONS
Purified botulinum toxin appears to be an effective treatment for crocodile tears.
目的
确定纯化的肉毒杆菌毒素在治疗“鳄鱼泪”（味觉性流泪）方面是否与治疗其他分泌过多综合征（如弗雷综合征，味觉性出汗）一样有效。
方法
一名弗雷综合征（味觉性出汗）患者成功接受了肉毒杆菌毒素治疗。此后，两名患有慢性症状性鳄鱼泪（与既往面神经麻痹有关）的患者接受了泪腺内及周围的肉毒杆菌毒素注射治疗。
结果
两名患者均报告症状明显缓解，且观察到进食时无流泪现象。
结论
纯化的肉毒杆菌毒素似乎是治疗鳄鱼泪的有效方法。
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