Steinberg Martin, Sheppard Jeannie-Marie, Tschanz JoAnn T, Norton Maria C, Steffens David C, Breitner John C S, Lyketsos Constantine G
Johns Hopkins Hospital, Baltimore, MD 21287, USA.
J Neuropsychiatry Clin Neurosci. 2003 Summer;15(3):340-5. doi: 10.1176/jnp.15.3.340.
A population-based prevalence sample of 355 residents of Cache County, Utah, who were diagnosed with dementia, was rated on the Neuropsychiatric Inventory (NPI). Of the 355 residents, 119 had no neuropsychiatric symptoms at baseline and were, consequently, at risk for incident mental and behavioral disturbances. The NPI was readministered approximately 18 months later to 61 surviving participants. Sixty-nine percent developed at least one mental or behavioral symptom. Delusions were most common (28%), followed by apathy (21%), and aberrant motor behavior (21%). When this incidence rate of 69% was combined with a previously estimated prevalence rate of 61%, the cumulative 18-month prevalence approached 90%. These results argue for a routine assessment of psychiatric disturbances in all patients with dementia, even among those who have never experienced symptoms of mental or behavioral disturbances.
对犹他州卡什县355名被诊断患有痴呆症的居民进行了基于人群的患病率抽样调查，并根据神经精神科问卷（NPI）进行评分。在这355名居民中，119人在基线时没有神经精神症状，因此有发生精神和行为障碍的风险。大约18个月后，对61名存活的参与者再次进行NPI测评。69%的人出现了至少一种精神或行为症状。妄想最为常见（28%），其次是冷漠（21%）和异常运动行为（21%）。当这69%的发病率与先前估计的61%的患病率相结合时，18个月的累积患病率接近90%。这些结果表明，应对所有痴呆症患者进行精神障碍的常规评估，即使是那些从未经历过精神或行为障碍症状的患者。
