Gómez-Espejo Carmen, Herrera-Sabal Alberto, Ríos-Martín Juan José, Camacho-Martínez Francisco
Department of Dermatology, Virgen Macarena Hospital, Seville, Spain.
J Dermatol. 2003 Jul;30(7):543-9. doi: 10.1111/j.1346-8138.2003.tb00430.x.
We report a new case of sarcomatoid carcinoma, which showed cellular features of basal cell carcinoma and malignant fibrous myxoid histiocytoma. For this new case and rare neoplasm, we propose the designation of sarcomatoid basal cell carcinoma, as both components were intimately intermingled, the spindle cells seemed to arise from epithelial cells, and both tumoral components showed the same immunohistochemistry expression, cytokeratin and P53 protein, suggesting a monoclonal origin. The epithelial component, a basal cell carcinoma, may have been the first component in the carcinogenesis process.
我们报告了一例新的肉瘤样癌病例，其表现出基底细胞癌和恶性纤维黏液样组织细胞瘤的细胞特征。对于这一新病例和罕见肿瘤，我们提议将其命名为肉瘤样基底细胞癌，因为两种成分紧密混合，梭形细胞似乎起源于上皮细胞，且两种肿瘤成分显示相同的免疫组化表达，即细胞角蛋白和P53蛋白，提示单克隆起源。上皮成分，即基底细胞癌，可能是致癌过程中的首个成分。
