Badhe Bhawana A, Iyengar Krishnan R, Alva Nandakishor
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry - 605 006, India.
Indian J Cancer. 2002 Jul-Sep;39(3):91-6.
Cytological parameters were studied in 18 fibroepithelial tumours of the breast including 8 benign phyllodes, 1 malignant phyllodes, and 9 fibroadenomas between 1999 to 2001. Cytology smears were studied without knowledge of previous cytodiagnosis by 3 different observers. Histopathologic parameters were studied in 18 fibroepithelial tumours by 3 observers. Cyto-histological correlation was carried out. Cytological criteria by Chinoy et al (1999) were utilized to give revised cytodiagnosis. Initial cytodiagnosis and revised cytodiagnosis were correlated with histopathological diagnosis. 8/9 cases of fibroadenoma (88%) studied were correctly diagnosed on FNAC after semiquantitative team approach as opposite to 44% initial cytodiagnosis. Cytological distinction between benign phyllodes and fibroadenoma was improved after semiquantitative approach to various parameters. Diagnosis of malignant phyllodes posed no problems in cytodiagnosis. Present study supports the role of FNAC in distinguishing benign from malignant phyllodes and distinguishing fibroadenoma from phyllodes tumour. The latter being a rare fibroepithelial tumour, its study is interesting.
1999年至2001年间,对18例乳腺纤维上皮性肿瘤进行了细胞学参数研究,其中包括8例良性叶状肿瘤、1例恶性叶状肿瘤和9例纤维腺瘤。由3名不同的观察者在不了解先前细胞诊断结果的情况下对细胞学涂片进行研究。3名观察者对18例纤维上皮性肿瘤进行了组织病理学参数研究。进行了细胞组织学相关性分析。采用Chinoy等人(1999年)的细胞学标准进行修订后的细胞诊断。将初始细胞诊断和修订后的细胞诊断与组织病理学诊断进行相关性分析。在采用半定量团队方法后,9例纤维腺瘤中有8例(88%)在细针穿刺抽吸活检(FNAC)中得到正确诊断,而初始细胞诊断的准确率为44%。在对各种参数采用半定量方法后,良性叶状肿瘤与纤维腺瘤之间的细胞学鉴别得到了改善。恶性叶状肿瘤的诊断在细胞诊断中没有问题。本研究支持FNAC在区分良性与恶性叶状肿瘤以及区分纤维腺瘤与叶状肿瘤中的作用。后者是一种罕见的纤维上皮性肿瘤,对其研究很有意义。