Haglind E
Department of Surgery, Sahlgren's Hospital, University of Göteborg, Sweden.
Circ Shock. 1992 Nov;38(3):195-201.
The effects of continuous naloxone infusion on the response to intestinal ischemia-reperfusion were studied in a rat model. Naloxone was given as a bolus injection (2 mg/kg bw) followed by a continuous infusion (4 mg/kg bw/h) starting before (-10 min) intestinal ischemia was applied (0-60 min) and continuing 2 h after reperfusion of the intestine. Blood pressure, acidosis and survival were determined. Saline-infused shocked rats and untreated shocked rats served as comparisons and non-shocked animals as controls. Blood pressure was slightly higher before and during the continuous naloxone infusion but did not differ after reperfusion in the three shock groups. Acidosis was less pronounced in naloxone compared to untreated shocked rats. Survival rates were significantly higher in naloxone-treated shocked rats compared to untreated shock and significantly lower in saline treated shocked rats compared to non-shocked controls. In conclusion a naloxone effect on acidosis and survival in shock after intestinal ischemia and reperfusion is possible.
在大鼠模型中研究了持续输注纳洛酮对肠缺血再灌注反应的影响。纳洛酮先给予一次推注（2毫克/千克体重），然后在肠缺血（0 - 60分钟）施加前（-10分钟）开始持续输注（4毫克/千克体重/小时），并在肠再灌注后持续2小时。测定血压、酸中毒情况和存活率。输注生理盐水的休克大鼠和未治疗的休克大鼠作为对照，未休克动物作为对照组。在持续输注纳洛酮期间及之前，三组休克大鼠的血压略高，但再灌注后无差异。与未治疗的休克大鼠相比，纳洛酮组的酸中毒不那么明显。与未治疗的休克大鼠相比，纳洛酮治疗的休克大鼠存活率显著更高，与未休克对照组相比，生理盐水治疗的休克大鼠存活率显著更低。总之，纳洛酮可能对肠缺血再灌注后休克的酸中毒和存活率有影响。
