Cetin Bahadir, Koçkaya E Arzu, Atalay Can, Akay M Turan, Cetin Abdullah
Department of General Surgery, Ankara Oncology Hospital, Ankara, Turkey.
Surg Today. 2003;33(9):688-92. doi: 10.1007/s00595-003-2578-3.
Pleurodesis is used to treat pleural effusions, and a number of agents with varying degrees of efficacy and systemic toxicity have been trialed. This study was conducted to evaluate the efficacy and systemic toxicity of polidocanol in pleurodesis.
Thirty albino Wistar rats were divided into three groups of ten rats each. Group 1 (control) was given isotonic saline, group 2 was given 35 mg/kg tetracycline, and group 3 was given 2.5 mg 0.5% polidocanol, all intrapleurally in a total volume of 0.5 ml. The rats were killed on postoperative day 30 and the macroscopic pleural adhesions and microscopic evidence of inflammation were evaluated. Hepatic, renal, and pancreatic function tests were done and various tissues were microscopically examined to detect systemic toxicity. The mean values of macroscopic and microscopic scoring and biochemical parameters were compared among the three groups.
The polidocanol- and tetracycline-treated rats had significantly more adhesions than the control group rats, and polidocanol was more effective for pleurodesis than tetracycline (P = 0.027). Microscopic scoring was similar in the polidocanol- and tetracycline-treated rats, being significantly higher than that in the control rats. No significant difference was found in the biochemical parameters among the three groups. There were no signs of toxicity in any of the tissues studied microscopically.
Polidocanol was found to be a more effective sclerosing agent than tetracycline for pleurodesis. Systemic toxicity was not shown by the biochemical parameters and histopathologic findings.
胸膜固定术用于治疗胸腔积液，已对多种疗效和全身毒性程度各异的药物进行了试验。本研究旨在评估聚多卡醇在胸膜固定术中的疗效和全身毒性。
将30只白化Wistar大鼠分为三组，每组10只。第1组（对照组）给予等渗盐水，第2组给予35mg/kg四环素，第3组给予2.5mg 0.5%聚多卡醇，均经胸腔内注射，总体积为0.5ml。术后第30天处死大鼠，评估宏观胸膜粘连和炎症的微观证据。进行肝功能、肾功能和胰腺功能测试，并对各种组织进行显微镜检查以检测全身毒性。比较三组之间宏观和微观评分以及生化参数的平均值。
聚多卡醇和四环素治疗的大鼠粘连明显多于对照组大鼠，聚多卡醇在胸膜固定术中比四环素更有效（P = 0.027）。聚多卡醇和四环素治疗的大鼠微观评分相似，均显著高于对照大鼠。三组之间生化参数无显著差异。在显微镜检查的任何组织中均未发现毒性迹象。
发现聚多卡醇在胸膜固定术中是比四环素更有效的硬化剂。生化参数和组织病理学结果未显示全身毒性。
