Wang Min, Xing Zhi-Min, Lu Chao, Ma You-Xiang, Yu De-Lin, Yan Zheng, Wang Shen-Wu, Yu Li-Sheng
Department of ENT, People's Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, 100044, Beijing, P.R. China.
Hum Genet. 2003 Oct;113(5):387-90. doi: 10.1007/s00439-003-1001-x. Epub 2003 Aug 20.
Allergic rhinitis is a major public health problem and has seen its prevalence increase during the past few decades. Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production. Single nucleotide polymorphisms (SNPs) have been found in both the coding sequence and the promoter region of IL-13, and such SNPs have been associated with allergic asthma. We have investigated whether IL-13 SNPs are associated with allergic rhinitis. Among 188 Chinese adult patients with allergic rhinitis and 87 normal controls, no significant difference was found in either allele or haplotype frequency of the SNPs between the two groups. Within patients, there was a significant association of the IL-13 Arg130Gln SNP, but not of the IL-13 promoter -1112(C/T) SNP, with serum total IgE levels. Patients with a Gln/Gln genotype showed much higher serum total IgE than those with an Arg/Arg genotype. When tested for serum-specific IgE, patients allergic to Derp 1, but not those allergic to Artemisia pollen, showed a significant association with the IL-13 promoter SNP. Thus, our results suggest a possible involvement of IL-13 SNPs in the regulation of IgE production in response to allergens in this Chinese population.
变应性鼻炎是一个主要的公共卫生问题，在过去几十年中其患病率有所上升。白细胞介素13（IL-13）与发病机制及免疫球蛋白E（IgE）产生的调节有关。在IL-13的编码序列和启动子区域均发现了单核苷酸多态性（SNP），且此类SNP与变应性哮喘相关。我们研究了IL-13 SNP是否与变应性鼻炎相关。在188例中国成年变应性鼻炎患者和87例正常对照中，两组间SNP的等位基因频率或单倍型频率均未发现显著差异。在患者中，IL-13 Arg130Gln SNP与血清总IgE水平存在显著关联，而IL-13启动子 -1112(C/T) SNP则无此关联。Gln/Gln基因型患者的血清总IgE水平显著高于Arg/Arg基因型患者。在检测血清特异性IgE时，对Derp 1过敏的患者，而非对蒿属花粉过敏的患者，其与IL-13启动子SNP存在显著关联。因此，我们的结果提示IL-13 SNP可能参与了该中国人群中针对变应原的IgE产生调节。
