[B-cell depletion in the treatment of rheumatoid arthritis].

作者信息

Feist Eugen, Burmester Gerd-R, Dörner Thomas

机构信息

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Universitätsklinikum Charité Humboldt-Universität zu Berlin, Berlin, Germany.

出版信息

Z Rheumatol. 2003 Aug;62(4):361-6. doi: 10.1007/s00393-003-0539-2.

New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent data of a temporary B cell depletion using a monoclonal anti-CD20 antibody in the therapeutic arsenal of rheumatoid arthritis.