Mulder E J, Visser G H
Department of Obstetrics and Gynaecology, Utrecht University Hospital, Netherlands.
Early Hum Dev. 1992 Dec;31(2):91-5. doi: 10.1016/0378-3782(92)90037-h.
In the first trimester of type-1 diabetic pregnancy, the embryo and fetus are often smaller than normal (early growth delay). We examined the impact of early growth delay on subsequent growth (birth weight) and functional development near term (organizational level of fetal behavioral states) in 21 and 10 fetuses of diabetic women, respectively. There was no relationship between the degree of early growth delay and birth weight (centiles). Mean growth delay per fetus in early diabetic pregnancy was negatively correlated with the occurrence of no-coincidence between behavioral state parameters at 36 weeks (R = -0.59; P < 0.05). These results indicate that disorders occurring in early life may underlie abnormal functional development in later life, whereas (catch up) growth is mainly determined during the second half of pregnancy.
在1型糖尿病孕妇的孕早期，胚胎和胎儿通常比正常情况小（早期生长延迟）。我们分别对21例和10例糖尿病孕妇的胎儿进行研究，观察早期生长延迟对随后的生长（出生体重）以及孕晚期功能发育（胎儿行为状态的组织水平）的影响。早期生长延迟的程度与出生体重（百分位数）之间没有关系。糖尿病孕早期每个胎儿的平均生长延迟与36周时行为状态参数之间无对应关系的发生率呈负相关（R = -0.59；P < 0.05）。这些结果表明，生命早期出现的紊乱可能是后期异常功能发育的基础，而（追赶）生长主要在妊娠后半期决定。
